Publications

The multiparametric MRI technology underpinning LiverMultiScan® was first published in two landmark papers from the University of Oxford, highlighting the utility for non-invasive diagnosis and staging of liver disease (Banerjee, R. et al. 2014-J. Hepatol) and prediction of clinical outcomes in patients with chronic liver disease (Pavlides, 2016-J. Hepatol.). Subsequent publications have demonstrated utility in fatty liver disease (Pavlides, 2016-Liver Int., Wilman, 2017, Eddowes, 2018) along with cost-effectiveness when incorporated into a clinical pathway (Blake, 2016).

In earlier posted publications there is mention of a LIF score which is a composite measure based on cT1, a metric provided by LiverMultiScan. LIF is a mapping of cT1 onto a 0-4 scale. cT1 has replaced LIF as the preferred metric for representing iron-corrected relaxation time of liver tissue. It is a direct metric shown to correlate with fibro-inflammation of liver tissue.

More of our publications are listed below.

Relationship between magnetic resonance imaging spleen T1 relaxation and other radiologic and clinical biomarkers of liver fibrosis in children and young adults with autoimmune liver disease.

Author: Dillman, J.R., Tkach, J.A., Gandhi, D., Singh, R., Miethke, A.G, Jayaswal, A., Trout, A.T.

Journal: Abdominal Radiology
Publication Year: 2020
Volume/Issue: Epub ahead of print
Pages:

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis

Author:

Parisinos, C.A., Wilman, H.R., Thomas, E.L, Kelly, M., Nicholls, R.C, McGonigle, J., Neubauer, J., Hingorani, A.D., Patel, R.S., Hemingway, H., Bell, J., Berjee, R., Yaghhotkar, H.

Journal: Journal of Hepatology
Publication Year: 2020
Volume/Issue: Epub ahead of print
Pages:

Quantitative MRCP Imaging: Accuracy, Repeatability, Reproducibility, and Cohort-Derived Normative Ranges

Author: Goldfinger, M.H., Ridgway, G.R., Ferreira, C., Langford, C.R., Cheng, L., Kazimianec, A., Borghetto, A., Wright, T.G., Woodward, G., Hassanali, N., Nicholls, R.C., Simpson, H., Waddell, T., Vikal, S., Mavar, M., Rymell, S., Wigley, I., Jacobs, J., Kelly, M., Banerjee, R. and Brady, J.M.

Journal: Journal of Magnetic Resonance Imaging
Publication Year: 2020
Volume/Issue: Epub ahead of print
Pages:

Nutrition and Nonalcoholic Fatty Liver Disease: Current Perspectives

Author:

Chakravarthy, M.V., Waddell, T., Banerjee, R., Guess, N.

Journal: Gastroenterology Clinics
Publication Year: 2019
Volume/Issue: 49(1)
Pages: 63-94

Differentiating pediatric autoimmune liver diseases by quantitative magnetic resonance cholangiopancreatography

Author: Gilligan, L.A., Trout, A.T., Lam, S., Singh, R., Tkach, J.A., Serai, S.D., Miethke, A.G., Dilman, J.R.

Journal: Abdominal Radiology
Publication Year: 2020
Volume/Issue: 45(1)
Pages: 168-176

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

Author: Wilman, H.R., Parisinos, C.A., Atabaki-Pasdar, N., Kelly, M., Thomas, E.L., Neubauer, S., IMI DIRECT Consortium, Mahajan, A., Hingorani, A.D., Patel, R.S., Hemingway, H., Franks, P.W., Bell, J.D., Banerjee, R., Yaghootkar, H.

Journal: Journal of Hepatology
Publication Year: 2019
Volume/Issue: 71(3)
Pages: 594-602

Non-invasive assessment of portal hypertension by multi-parametric magnetic resonance imaging of the spleen: A proof of concept study

Author: Levick, C., Phillips-Hughes, J., Collier, J., Banerjee, R., Cobbold, J. F., Wang, L. M., Piechnik, S. K., Robson, M. D., Neubauer, S., Barnes, E., Pavlides, M.

Journal: PLOS ONE
Publication Year: 2019
Volume/Issue: 14(8)
Pages: e0221066

Repeatability and reproducibility of multiparametric magnetic resonance imaging of the liver

Author: Bachtiar, V., Kelly, M.D., Wilman, H.R., Jacobs, J., Newbould, R., Kelly, C.J., Gyngell, M.L., Groves, K.E., McKay, A., Herlihy, A.H., Fernandes, C.C., Halberstadt, M., Maguire, M., Jayaratne, N., Linden, S., Neubauer, S., Banerjee, R.

Journal: PLOS ONE
Publication Year: 2019
Volume/Issue: 14(4)
Pages: e0214921

Magnitude‐intrinsic water–fat ambiguity can be resolved with multipeak fat modeling and a multipoint search method

Author: Bagur, A.T., Hutton, C., Irving, B., Gyngell, M.L., Robson, M.D., Brady, M. 

Journal: Magnetic Resonance in Medicine
Publication Year: 2019
Volume/Issue: 82(1)
Pages: 460-475

NGM282 Improves Liver Fibrosis and Histology in 12 Weeks in Patients With Nonalcoholic Steatohepatitis

Author: Harrison, S.A., Rossi, S.J., Paredes, A.H., Trotter, J.F., Bashir, M.R., Guy, C.D., Banerjee, R., Jaros, M.J, Owers, S., Baxter, B.A., Ling, L., DePaoli, A.M.

Journal: Journal of Hepatology
Publication Year: 2019
Volume/Issue:
Pages:

Reference range of liver corrected T1 values in a population at low risk for fatty liver disease—a UK Biobank sub-study, with an appendix of interesting cases

Author: Mojtahed, A., Kelly, C. J., Herlihy, A. H., Kin, S., Wilman, H. R., McKay, A., Kelly, M., Milanesi, M., Neubauer, S., Thomas, E. L., Bell, J. D., Banerjee, R., & Harisinghani, M.

Journal: Abdominal Radiology
Publication Year: 2019
Volume/Issue: 44(1)
Pages: 72-84

Measurement of liver iron by magnetic resonance imaging in the UK Biobank population

Author: McKay, A., Wilman, H. R., Dennis, A., Kelly, M., Gyngell, M. L., Neubauer, S., Bell, J. D., Banerjee, R., & Thomas, E. L.

Journal: PLOS ONE
Publication Year: 2018
Volume/Issue: 13(12)
Pages: e0209340

[Poster] Repeatability and Reproducibility of Multiparametric Magnetic Resonance Imaging of the Liver

Author: Henry Wilman, Velicia Bachtiar, Jaco Jacobs, Rex Newbould, Michael Gyngell, Cat Kelly, Matt Kelly, Stefan Neubauer, Rajarshi Banerjee.

Journal: Journal of Hepatology
Publication Year: 2018
Volume/Issue: Volume 68, Supplement 1
Pages: S562, Abstract: FRI-443

[Poster] The “IDEAL” method for fat quantification and iron-corrected T1 accurately measure the presence and severity of the individual histological features of nonalcoholic steatohepatitis (NASH)

Author: Siddiqui, M., Grawenda, A., Cadrain, R., Collen, R., Steinberg, J., Luketic, V., Dennis, A., Hildick, K., Kelly, M.D., Neubauer, S., Banerjee, R., and Sanyal, A.

Journal: Hepatology
Publication Year: 2018
Volume/Issue: 68(1)
Pages: 1322 Abstract 2338

Stratification of biliary disease with quantitative MRCP (MRCP+)

Author: Woodward, G., Mavar, M., Ridgway, G., Halberstadt, M., McKay, A., Kelly, M., Neubauer, S., Brady, M., Banerjee, R. 

Journal: Hepatology
Publication Year: 2018
Volume/Issue: Volume 68, Issue 1
Pages: 1111 Abstract 1952

Cross-sectional, prospective, evaluation of the utility of Multi-parametric MRI imaging in predicting clinically meaningful outcomes in autoimmune hepatitis

Author: Arndtz K, Hodson J, Eddowes P, Kelly MD, Dennis A, Fiore M, Banerjee R, Neubauer S, Hirschfield GM

Journal: Hepatology
Publication Year: 2018
Volume/Issue: Volume 68, Issue 1
Pages: 1116 Abstract 1961

Multi-parametric MRI imaging in a heterogeneous liver disease: cross-sectional evaluation of a cohort of patients with PSC

Author: Arndtz K, Hodson J, Eddowes P, Kelly M, Dennis A, Fiore M, Green D, Banerjee R, Neubauer S, Hirschfield GM

Journal: Hepatology
Publication Year: 2018
Volume/Issue: Volume 68, Issue 1
Pages: 1090 Abstract 1917

Multi-parametric MRI as a composite biomarker for NASH and NASH with fibrosis

Author: McKay, A, Dennis, A, Kelly, M, Fallowfiled, J, Hirschfield,G, Neubauer, S, Banerjee, R

Journal: Hepatology
Publication Year: 2018
Volume/Issue: Volume 68, Issue 1
Pages: 954 Abstract 1677

Liver cT1 predicts clinical outcomes in patients with chronic liver disease, equivalent to biopsy

Author: Jayaswal, A, Pavlides, M, Banerjee, R, Kelly, M, Barnes, E, Neubauer, S

Journal: Hepatology
Publication Year: 2018
Volume/Issue: Volume 68, Issue 1
Pages: 607 Abstract 1042

The cT1 multi-parametric MRI value is more sensitive and reliable than transient elastography for the non-invasive monitoring of intra-hepatic inflammation/fibrosis response to DAA therapy in CHC patients

Author: Salvati A, Martini N, McKay, A, Faita F, Coco B, Colombatto P, Ricco G, Oliveri F, Romagnoli V, Bonino F, Chiappino D and Brunetto MR

Journal: Hepatology
Publication Year: 2018
Volume/Issue: Volume 68, Issue 1
Pages: 362 Abstract 609

Matrix Metalloproteinase 7 (MMP7) as a Biomarker of Sclerosing Cholangitis in Pediatric Autoimmune Liver Disease

Author: Lam, S., Singh, R., Dillman, J.R., Serai, S.D., Trout, A.T., Sheridan, R., Sharma, D., Su, W., Blaxall, B.C., Haramija, M.M., Ridgway, G., Woodward, G., Miethke, A.J.

Journal: Hepatology
Publication Year: 2018
Volume/Issue: Volume 68
Pages: 115 Abstract 183

Validation of a standardized MRI method for liver fat and T2* quantification

Author: Hutton, C., Gyngell, M.L., Milanesi, M., Bagur, A., Brady, M. 

Journal: PLOS ONE
Publication Year: 2018
Volume/Issue: 13(9)
Pages: e0204175

Mapping tissue water T1 in the liver using the MOLLI T1 method in the presence of fat, iron and B0 inhomogeneity

Author: Ferenc E. Mozes, F.E. Tunnicliffe, E.M., Moolla, A., Marjot, T.  Levick, C.K., Pavlides, M., Robson, M.D.

Journal: NMR in Biomedicine
Publication Year: 2018
Volume/Issue: 32 e4030
Pages: e4030

Utility and variability of three non-invasive liver fibrosis imaging modalities to evaluate efficacy of GR-MD-02 in subjects with NASH and bridging fibrosis during a phase-2 randomized clinical trial

Author: Harrison, S. A., Dennis, A., Fiore, M. M., Kelly, M. D., Kelly, C. J., Paredes, A. H., Whitehead, J. M., Neubauer, S., Traber, P. G., & Banerjee, R. 

Journal: PLOS ONE
Publication Year: 2018
Volume/Issue: 13(9)
Pages: e0203054

Study protocol: HepaT1ca – an observational clinical cohort study to quantify liver health in surgical candidates for liver malignancies

Author: Mole, D. J., Fallowfield, J. A., Kendall, T. J., Welsh, F., Semple, S. I., Bachtiar, V., Kelly, M., Wigmore, S. J., James Garden, O., Wilman, H. R., Banerjee, R., Rees, M., & Brady, M. 

Journal: BMC Cancer
Publication Year: 2018
Volume/Issue: 18(1)
Pages: 890

Multiparametric magnetic resonance imaging for quantitation of liver disease: a two-centre cross-sectional observational study

Author: McDonald N, Eddowes PJ, Hodson J, Semple SIK, Davies NP, Kelly CJ, Kin S, Phillips M, Herlihy AH, Kendall TJ, Brown RM, Neil DAH, Hübscher SG, Hirschfield GM, Fallowfield JA.

Journal: Scientific Reports
Publication Year: 2018
Volume/Issue: 8
Pages: Article 9189

Non-invasive assessment of liver disease in rats using multiparametric magnetic resonance imaging: a feasibility study

Author: Anna M. Hoy, Natasha McDonald, Ross J. Lennen, Matteo Milanesi, Amy H. Herlihy, Timothy J. Kendall, William Mungall, Michael Gyngell, Rajarshi Banerjee, Robert L. Janiczek, Philip S. Murphy, Maurits A. Jansen, Jonathan A. Fallowfield

Journal: Biology Open
Publication Year: 2018
Volume/Issue: 7
Pages:

Multiparametric magnetic resonance imaging for early detection of diffuse liver disease

Author: Breen, D.

Journal: Biomarkers in Medicine
Publication Year: 2018
Volume/Issue: Accepted, in Press
Pages:

Interobserver Variability in Histologic Evaluation of Liver Fibrosis Using Categorical and Quantitative Scores

Author: Michael Pavlides, DPhil Jacqueline Birks, PhD Eve Fryer, BMBCh David Delaney, MD Nikita Sarania, MBChB Rajarshi Banerjee, DPhil Stefan Neubauer, PhD Eleanor Barnes, PhD Kenneth A. Fleming, DPhil Lai Mun Wang, MBBCh

Journal: American Journal of Clinical Pathology
Publication Year: 2017
Volume/Issue: 147/4
Pages: 364–369

A model for hepatic fibrosis: the competing effects of cell loss and iron on shortened modified Look‐Locker inversion recovery T1 (shMOLLI‐T1) in the liver

Author: Elizabeth M. Tunnicliffe PhD, Rajarshi Banerjee DPhil, Michael Pavlides DPhil, Stefan Neubauer MD, Matthew D. Robson PhD

Journal: Journal of magnetic resonance imaging : JMRI
Publication Year: 2017
Volume/Issue: 45/2
Pages: 450-462

Multi-parametric magnetic resonance imaging for the assessment of non-alcoholic fatty liver disease severity

Author: Pavlides, M., Banerjee, R., Tunnicliffe, E. M., Kelly, C., Collier, J., Wang, L. M., Fleming, K. A., Cobbold, J. F., Robson, M. D., Neubauer, S., Barnes, E

Journal: Liver International
Publication Year: 2017
Volume/Issue:
Pages: 1-9

Characterisation of liver fat in the UK Biobank cohort

Author: Wilman, H. R., Kelly, M., Garratt, S., Matthews, P. M., Milanesi, M., Herlihy, A., Gyngell, M., Neubauer, S., Bell, J. D., Banerjee, R., Thomas, E. L

Journal: PLoS One
Publication Year: 2017
Volume/Issue: 12(2)
Pages: e0172921

Utility and cost evaluation of multiparametric magnetic resonance imaging for the assessment of non-alcoholic fatty liver disease

Author: Eddowes, P., McDonald, N., Davies, N., Semple, S., Kendall, T., Hodson, J., Newsome, P., Flintham, R., Wesolowski, R., Blake, L., Duarte, R., Kelly, C.J., Herlihy, A., Kelly, M.D., Olliff, S., Hubscher, S., Fallowfield, J., Hirschfield, G.

Journal: Alimentary Pharmacology & Therapeutics
Publication Year: 2017
Volume/Issue: 00
Pages: 1–14

Patient reported assessment of different diagnostic imaging tests for liver disease visual representation and ownership of results improves understanding.

Author: Andrew G. McKay, Arjun Jayaswal, Matteo Milanesi, Miranda Phillips, Stella Kin, Xiaojun Xu, Joana Leal, Rajarshi Banerjee

Journal: Hepatology
Publication Year: 2016
Volume/Issue: Volume 64, Issue S1
Pages: i-ii, 1-1117, Abstract 1743

Ectopic and visceral fat deposition in lean and obese patients with Type 2 Diabetes

Author: Levelt, E., Pavlides, M., Banerjee, R., Mahmod, M., Kelly, C., Sellwood, J., Ariga, R., Thomas, S., Francis, J., Rodgers, C., Clarke, W., Sabharwal, N., Antoniades, C., Schneider, J., Robson, M., Clarke, K., Karamitsos, T., Rider, O., Neubauer, S

Journal: Journal of the American College of Cardiology
Publication Year: 2016
Volume/Issue: 68
Pages: 53-63

Decision analytic model of the diagnostic pathways for patients with suspected non-alcoholic fatty liver disease using non-invasive transient elastography and multiparametric magnetic resonance imaging

Author: Blake, L., Duarte, R. V., Cummins, C.

Journal: BMJ Open
Publication Year: 2016
Volume/Issue: 6(9)
Pages: e010507

Investigating a Liver Fat: Arterial Stiffening Pathway in Adult and Childhood Obesity

Author: Rider, O. J., Banerjee, R., Rayner, J. J., Shah, R., Murthy, V. L., Robson, M. D., Neubauer, S

Journal: Arteriosclerosis Thrombosis and Vascular Biology
Publication Year: 2016
Volume/Issue: 36
Pages: 198-203

Multiparametric magnetic resonance imaging predicts clinical outcomes in patients with chronic liver disease

Author: Pavlides, M., Banerjee, R. Sellwood, J. Kelly, C, Robson, M.D., Booth, J.C., Collier, J., Neubauer, S., Barnes, E

Journal: Journal of Hepatology
Publication Year: 2016
Volume/Issue: 64
Pages: 308-315

Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women

Author: Hodson, L., Banerjee, R., Rial, B., Arlt, W., Adiels, M., Boren, J., Marinou, K., Fisher, C., Mostad, I. L., Stratton, I. M., Barrett, P. H., Chan, D. C., Watts, G. F, Harnden, K., Karpe, F., Fielding, B. A

Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Publication Year: 2015
Volume/Issue: 4(10)
Pages: e002258

Sex-specific differences in hepatic fat oxidation and synthesis may explain the higher propensity for NAFLD in men

Author: Pramfalk, C., Pavlides, M., Banerjee, R., McNeil, C.A., Neubauer, S., Karpe, F., Hodson, L.

Journal: Journal of Clinical Endocrinology and Metabolism
Publication Year: 2015
Volume/Issue: 100(12)
Pages: 4425-33

Evidence of a Direct Effect of Myocardial Steatosis on LV Hypertrophy and Diastolic Dysfunction in Adult and Adolescent Obesity

Author: Banerjee, R., Rial, B., Holloway, C.J., Lewandowski, A.J., Robson, M.D., Osuchukwu, C., Schneider, J.E., Leeson, P., Rider, O.J., Neubauer, S.

Journal: JACC: Cardiovascular Imaging
Publication Year: 2015
Volume/Issue: 8(12)
Pages: 1468-1470

Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease

Author: Banerjee, R., Pavlides, M., Tunnicliffe, E. M., Piechnik, S. K., Sarania, N., Philips, R., Collier J. D., Booth, J. C., Schneider, J. E., Wang, L. M., Delaney, D. W., Fleming, K. A., Robson, M. D., Barnes, E., Neubauer, S.

Journal: Journal of Hepatology
Publication Year: 2014
Volume/Issue: 60(1)
Pages: 69–77

Rapid quantification of myocardial lipid content in humans using single breath‐hold 1H MRS at 3 Tesla

Author: Rial, B., Robson, M.D., Neubauer, S., Schneider, J.E.

Journal: Magnetic Resonance in Medicine
Publication Year: 2011
Volume/Issue: 66(3)
Pages: 619-624