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Publications
The multiparametric MRI technology underpinning LiverMultiScan® was first published in two landmark papers from the University of Oxford, highlighting the utility for non-invasive diagnosis and staging of liver disease (Banerjee, R. et al. 2014-J. Hepatol) and prediction of clinical outcomes in patients with chronic liver disease (Pavlides, 2016-J. Hepatol.). Subsequent publications have demonstrated utility in fatty liver disease (Pavlides, 2016-Liver Int., Wilman, 2017, Eddowes, 2018) along with cost-effectiveness when incorporated into a clinical pathway (Blake, 2016).
In earlier posted publications there is mention of a LIF score which is a composite measure based on cT1, a metric provided by LiverMultiScan. LIF is a mapping of cT1 onto a 0-4 scale. cT1 has replaced LIF as the preferred metric for representing iron-corrected relaxation time of liver tissue. It is a direct metric shown to correlate with fibro-inflammation of liver tissue.
More of our publications are listed below.
Quantitative multiparametric MRI allows safe surgical planning in patients undergoing liver resection for colorectal liver metastases: report of two patients
Journal: BJR | case reports
Publication Year: 2021
Volume/Issue: 6
Pages: 20200172
Multiparametric MRI imaging, autoimmune hepatitis, and prediction of disease activity
Journal: Hepatology Communications
Publication Year: 2021
Volume/Issue: Accepted for publication
Pages:
Quantitative multiparametric MRI can aid NASH diagnosis in a Japanese cohort
Journal: World Journal of Gastroenterology
Publication Year: 2020
Volume/Issue: Accepted for publication
Pages:
Correlations between MRI biomarkers PDFF and cT1 with histopathological features of non-alcoholic steatohepatitis
Journal: Frontiers in Endocrinology
Publication Year: 2020
Volume/Issue: Provisionally accepted
Pages:
Liver cT1 decreases following direct-acting antiviral therapy in patients with chronic hepatitis C virus
Journal: Abdominal Radiology
Publication Year: 2020
Volume/Issue: Advance online publication
Pages:
Quantitative magnetic resonance imaging predicts individual future liver performance after liver resection for cancer
Journal: PLOS ONE
Publication Year: 2020
Volume/Issue: 15(12)
Pages: e0238568.
Serum Matrix Metalloproteinase 7 Is a Diagnostic Biomarker of Biliary Injury and Fibrosis in Pediatric Autoimmune Liver Disease
Journal: Hepatology Communications
Publication Year: 2020
Volume/Issue: 4(11)
Pages: 1680 - 1693
The Effect of Multiparametric Magnetic Resonance Imaging in Standard of Care for Non-alcoholic Fatty Liver Disease: Protocol for a Randomised Control Trial
Journal: JMIR Research Protocols
Publication Year: 2020
Volume/Issue: 9(10)
Pages: e19189
Multiparametric MRI as a non-invasive monitoring tool for children with autoimmune hepatitis
Journal: Journal of Pediatric Gastroenterology and Nutrition
Publication Year: 2020
Volume/Issue: Advance online publication
Pages:
A composite biomarker using multiparametric magnetic resonance imaging and blood analytes accurately identifies patients with non-alcoholic steatohepatitis and significant fibrosis
Journal: Scientific Reports
Publication Year: 2020
Volume/Issue: 10(1)
Pages: 15308
rs641738C>T near MBOAT7 is associated with liver fat, ALT, and fibrosis in NAFLD: a meta-analysis
Journal: Journal of Hepatology
Publication Year: 2020
Volume/Issue: Advance online publication
Pages:
Multiparametric MRI in Patients With Nonalcoholic Fatty Liver Disease
Journal: Journal of Magnetic Resonance Imaging
Publication Year: 2020
Volume/Issue: Advance online publication
Pages:
Multiparametric MR mapping in clinical decision-making for diffuse liver disease
Journal: Abdominal Radiology
Publication Year: 2020
Volume/Issue: 45(11)
Pages: 3507–3522.
Prognostic value of multiparametric magnetic resonance imaging, transient elastography and blood-based fibrosis markers in patients with chronic liver disease
Journal: Liver international
Publication Year: 2020
Volume/Issue: Advance online publication
Pages:
Mechanisms, screening modalities and treatment options for individuals with non-alcoholic fatty liver disease and type 2 diabetes
Journal: Diabetic medicine
Publication Year: 2020
Volume/Issue: 37(11)
Pages: 1793–1806
New boundaries of liver imaging: from morphology to function
Journal: European Journal of Internal Medicine
Publication Year: 2020
Volume/Issue: 79
Pages: 12–22
Comparison of liver T1 relaxation times without and with iron correction in pediatric autoimmune liver disease
Journal: Pediatric Radiology
Publication Year: 2020
Volume/Issue: 50(7)
Pages: 935–942.
Relationship between magnetic resonance imaging spleen T1 relaxation and other radiologic and clinical biomarkers of liver fibrosis in children and young adults with autoimmune liver disease.
Journal: Abdominal Radiology
Publication Year: 2020
Volume/Issue: 45(11)
Pages: 3709–3715
Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis
Journal: Journal of Hepatology
Publication Year: 2020
Volume/Issue: 73(2)
Pages: 241–251
Quantitative MRCP Imaging: Accuracy, Repeatability, Reproducibility, and Cohort-Derived Normative Ranges
Journal: Journal of Magnetic Resonance Imaging
Publication Year: 2020
Volume/Issue: 52(3)
Pages: 807–820
Nutrition and Nonalcoholic Fatty Liver Disease: Current Perspectives
Journal: Gastroenterology Clinics
Publication Year: 2019
Volume/Issue: 49(1)
Pages: 63-94
Differentiating pediatric autoimmune liver diseases by quantitative magnetic resonance cholangiopancreatography
Journal: Abdominal Radiology
Publication Year: 2020
Volume/Issue: 45(1)
Pages: 168-176
Sodium-glucose cotransporter 2 inhibition does not reduce hepatic steatosis in overweight, insulin-resistant patients without type 2 diabetes
Journal: JGH Open
Publication Year: 2019
Volume/Issue: 4(3)
Pages: 433–440.
Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration
Journal: Journal of Hepatology
Publication Year: 2019
Volume/Issue: 71(3)
Pages: 594-602
Non-invasive assessment of portal hypertension by multi-parametric magnetic resonance imaging of the spleen: A proof of concept study
Journal: PLOS ONE
Publication Year: 2019
Volume/Issue: 14(8)
Pages: e0221066
Repeatability and reproducibility of multiparametric magnetic resonance imaging of the liver
Journal: PLOS ONE
Publication Year: 2019
Volume/Issue: 14(4)
Pages: e0214921
Magnitude‐intrinsic water–fat ambiguity can be resolved with multipeak fat modeling and a multipoint search method
Journal: Magnetic Resonance in Medicine
Publication Year: 2019
Volume/Issue: 82(1)
Pages: 460-475
NGM282 Improves Liver Fibrosis and Histology in 12 Weeks in Patients With Nonalcoholic Steatohepatitis
Journal: Journal of Hepatology
Publication Year: 2019
Volume/Issue:
Pages:
Reference range of liver corrected T1 values in a population at low risk for fatty liver disease—a UK Biobank sub-study, with an appendix of interesting cases
Journal: Abdominal Radiology
Publication Year: 2019
Volume/Issue: 44(1)
Pages: 72-84
Measurement of liver iron by magnetic resonance imaging in the UK Biobank population
Journal: PLOS ONE
Publication Year: 2018
Volume/Issue: 13(12)
Pages: e0209340
[Poster] Repeatability and Reproducibility of Multiparametric Magnetic Resonance Imaging of the Liver
Journal: Journal of Hepatology
Publication Year: 2018
Volume/Issue: Volume 68, Supplement 1
Pages: S562, Abstract: FRI-443
[Poster] The “IDEAL” method for fat quantification and iron-corrected T1 accurately measure the presence and severity of the individual histological features of nonalcoholic steatohepatitis (NASH)
Journal: Hepatology
Publication Year: 2018
Volume/Issue: 68(1)
Pages: 1322 Abstract 2338
Multiparametric magnetic resonance imaging for early detection of diffuse liver disease
Journal: Biomarkers in Medicine
Publication Year: 2018
Volume/Issue: Accepted, in Press
Pages:
Stratification of biliary disease with quantitative MRCP (MRCP+)
Journal: Hepatology
Publication Year: 2018
Volume/Issue: Volume 68, Issue 1
Pages: 1111 Abstract 1952
Cross-sectional, prospective, evaluation of the utility of Multi-parametric MRI imaging in predicting clinically meaningful outcomes in autoimmune hepatitis
Journal: Hepatology
Publication Year: 2018
Volume/Issue: Volume 68, Issue 1
Pages: 1116 Abstract 1961
Multi-parametric MRI imaging in a heterogeneous liver disease: cross-sectional evaluation of a cohort of patients with PSC
Journal: Hepatology
Publication Year: 2018
Volume/Issue: Volume 68, Issue 1
Pages: 1090 Abstract 1917
Multi-parametric MRI as a composite biomarker for NASH and NASH with fibrosis
Journal: Hepatology
Publication Year: 2018
Volume/Issue: Volume 68, Issue 1
Pages: 954 Abstract 1677
Liver cT1 predicts clinical outcomes in patients with chronic liver disease, equivalent to biopsy
Journal: Hepatology
Publication Year: 2018
Volume/Issue: Volume 68, Issue 1
Pages: 607 Abstract 1042
The cT1 multi-parametric MRI value is more sensitive and reliable than transient elastography for the non-invasive monitoring of intra-hepatic inflammation/fibrosis response to DAA therapy in CHC patients
Journal: Hepatology
Publication Year: 2018
Volume/Issue: Volume 68, Issue 1
Pages: 362 Abstract 609
Matrix Metalloproteinase 7 (MMP7) as a Biomarker of Sclerosing Cholangitis in Pediatric Autoimmune Liver Disease
Journal: Hepatology
Publication Year: 2018
Volume/Issue: Volume 68
Pages: 115 Abstract 183
Validation of a standardized MRI method for liver fat and T2* quantification
Journal: PLOS ONE
Publication Year: 2018
Volume/Issue: 13(9)
Pages: e0204175
Mapping tissue water T1 in the liver using the MOLLI T1 method in the presence of fat, iron and B0 inhomogeneity
Journal: NMR in Biomedicine
Publication Year: 2018
Volume/Issue: 32 e4030
Pages: e4030
Utility and variability of three non-invasive liver fibrosis imaging modalities to evaluate efficacy of GR-MD-02 in subjects with NASH and bridging fibrosis during a phase-2 randomized clinical trial
Journal: PLOS ONE
Publication Year: 2018
Volume/Issue: 13(9)
Pages: e0203054
Study protocol: HepaT1ca – an observational clinical cohort study to quantify liver health in surgical candidates for liver malignancies
Journal: BMC Cancer
Publication Year: 2018
Volume/Issue: 18(1)
Pages: 890
Multiparametric magnetic resonance imaging for quantitation of liver disease: a two-centre cross-sectional observational study
Journal: Scientific Reports
Publication Year: 2018
Volume/Issue: 8
Pages: Article 9189
Non-invasive assessment of liver disease in rats using multiparametric magnetic resonance imaging: a feasibility study
Journal: Biology Open
Publication Year: 2018
Volume/Issue: 7
Pages:
Interobserver Variability in Histologic Evaluation of Liver Fibrosis Using Categorical and Quantitative Scores
Journal: American Journal of Clinical Pathology
Publication Year: 2017
Volume/Issue: 147/4
Pages: 364–369
A model for hepatic fibrosis: the competing effects of cell loss and iron on shortened modified Look‐Locker inversion recovery T1 (shMOLLI‐T1) in the liver
Journal: Journal of magnetic resonance imaging : JMRI
Publication Year: 2017
Volume/Issue: 45/2
Pages: 450-462
Multi-parametric magnetic resonance imaging for the assessment of non-alcoholic fatty liver disease severity
Journal: Liver International
Publication Year: 2017
Volume/Issue:
Pages: 1-9
Characterisation of liver fat in the UK Biobank cohort
Journal: PLoS One
Publication Year: 2017
Volume/Issue: 12(2)
Pages: e0172921
Utility and cost evaluation of multiparametric magnetic resonance imaging for the assessment of non-alcoholic fatty liver disease
Journal: Alimentary Pharmacology & Therapeutics
Publication Year: 2017
Volume/Issue: 00
Pages: 1–14
Patient reported assessment of different diagnostic imaging tests for liver disease visual representation and ownership of results improves understanding.
Journal: Hepatology
Publication Year: 2016
Volume/Issue: Volume 64, Issue S1
Pages: i-ii, 1-1117, Abstract 1743
Ectopic and visceral fat deposition in lean and obese patients with Type 2 Diabetes
Journal: Journal of the American College of Cardiology
Publication Year: 2016
Volume/Issue: 68
Pages: 53-63
Decision analytic model of the diagnostic pathways for patients with suspected non-alcoholic fatty liver disease using non-invasive transient elastography and multiparametric magnetic resonance imaging
Journal: BMJ Open
Publication Year: 2016
Volume/Issue: 6(9)
Pages: e010507
Investigating a Liver Fat: Arterial Stiffening Pathway in Adult and Childhood Obesity
Journal: Arteriosclerosis Thrombosis and Vascular Biology
Publication Year: 2016
Volume/Issue: 36
Pages: 198-203
Multiparametric magnetic resonance imaging predicts clinical outcomes in patients with chronic liver disease
Journal: Journal of Hepatology
Publication Year: 2016
Volume/Issue: 64
Pages: 308-315
Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women
Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Publication Year: 2015
Volume/Issue: 4(10)
Pages: e002258
Sex-specific differences in hepatic fat oxidation and synthesis may explain the higher propensity for NAFLD in men
Journal: Journal of Clinical Endocrinology and Metabolism
Publication Year: 2015
Volume/Issue: 100(12)
Pages: 4425-33
Evidence of a Direct Effect of Myocardial Steatosis on LV Hypertrophy and Diastolic Dysfunction in Adult and Adolescent Obesity
Journal: JACC: Cardiovascular Imaging
Publication Year: 2015
Volume/Issue: 8(12)
Pages: 1468-1470
Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease
Journal: Journal of Hepatology
Publication Year: 2014
Volume/Issue: 60(1)
Pages: 69–77
Rapid quantification of myocardial lipid content in humans using single breath‐hold 1H MRS at 3 Tesla
Journal: Magnetic Resonance in Medicine
Publication Year: 2011
Volume/Issue: 66(3)
Pages: 619-624