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Decision analytic model of the diagnostic pathways for patients with suspected non-alcoholic fatty liver disease using non-invasive transient elastography and multiparametric magnetic resonance imaging
Blake, L., et al. (2016)
BMJ Open
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The inclusion of LiverMultiScan, either as an adjunct to or replacement of transient elastography (TE) in the diagnostic pathway of NAFLD, leads to cost savings for the NHS by reducing the number of liver biopsies required. When used in place of TE and liver biopsy, LiverMultiScan remains cost-effective up to a price of £672.
A model for hepatic fibrosis: the competing effects of cell loss and iron on shortened modified Look-Locker inversion recovery T1 (shMOLLI-T1) in the liver
Tunnicliffe, E. M., et al. (2016)
Journal of Magnetic Resonance Imaging
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Validation of the technology underpinning cT1: iron correction of liver T1 values produces more accurate measurement of hepatic fibroinflammation.
Ectopic and visceral fat deposition in lean and obese patients with type 2 diabetes
Levelt, E., et al. (2016)
Journal of the American College of Cardiology
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LiverMultiScan showed elevated hepatic fibroinflammatory and fat levels in asymptomatic patients with type 2 diabetes, suggesting significant NAFLD and NASH. This highlights an urgent need – and potential application of the technology – in screening, staging and monitoring diabetic liver disease.
Multiparametric magnetic resonance imaging predicts clinical outcomes in patients with chronic liver disease
Pavlides, M., et al. (2016)
Journal of Hepatology
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LiverMultiScan demonstrated 100% negative predictive value for liver-related clinical outcomes, in patients monitored for up to 40 months. This holds prognostic potential for stratification of patients to facilitate clinical management and clinical trials.
Sex-specific differences in hepatic fat oxidation and synthesis may explain the higher propensity for NAFLD in men
Pramfalk, C., et al. (2015)
Journal of Clinical Endocrinology and Metabolism
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Men were observed to have a higher prevalence and greater risk of NAFLD compared with women despite similar levels of hepatic fat content. This is potentially driven by sex- specific differences in fatty acid metabolism.
Investigating a liver fat: arterial stiffening pathway in adult and childhood obesity
Rider, O., et al. (2015)
Arteriosclerosis, Thrombosis, and Vascular Biology
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Hepatic fat measured by 1H-MRS is related to increased aortic stiffness in both adults and children. Hepatic fat content is a potential therapeutic target to treat the elevated vascular risk in obesity, which requires reliable biomarkers for monitoring response to treatment.
Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women
Hodson, L., et al. (2015)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
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First study to report that abdominal obesity in women, and post-menopausal weight gain, are major drivers of very low-density lipoprotein secretion, which may increase risk of cardiovascular disease.
Evidence of a Direct Effect of Myocardial Steatosis on LV Hypertrophy and Diastolic Dysfunction in Adult and Adolescent Obesity
Banerjee, R., et al. (2015)
JACC: Cardiovascular Imaging
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Proton MRS (1H-MRS) and cardiac MRI showed that even in the absence of other comorbidities, adult and childhood obesity is related to cardiac steatosis. Higher myocardial triglyceride content relates to diastolic dysfunction, stronger in males. The findings suggest that cardiac steatosis occurs early in obesity and significantly affects childhood.
Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease
Banerjee, R., et al. (2013)
Journal of Hepatology
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First clinical validation showing that LiverMultiScan accurately stages chronic liver disease and has high diagnostic accuracy for assessment of liver fibrosis, steatosis and haemosiderosis. This is the first demonstration of a non-invasive test differentiating early stages of fibrosis from normal liver with high diagnostic accuracy.
Rapid quantification of myocardial lipid content in humans using single breath hold 1H MRS at 3 Tesla
Rial, B., et al. (2011)
Magnetic Resonance in Medicine
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Cardiac lipid levels measured using rapid single breath-hold 1H-magnetic resonance spectroscopy (1H-MRS) at 3T shows excellent correlation with results obtained by averaging over seven multiple breath-holds. This study demonstrates that single breath-hold 1H-MRS at 3T is a rapid and reliable method to quantify myocardial lipids.