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Comparison of liver T1 relaxation times without and with iron correction in pediatric autoimmune liver disease
Dillman, J. R., et al. (2020)
Pediatric Radiology
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In pediatric autoimmune liver disease, LiverMultiScan showed an excellent positive correlation between liver native T1 and iron-corrected cT1 in a cross-sectional study, suggesting limited iron confounding in this cohort.
Relationship between magnetic resonance imaging spleen T1 relaxation and other radiologic and clinical biomarkers of liver fibrosis in children and young adults with autoimmune liver disease
Dillman, J. R., et al. (2020)
Abdominal Radiology
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In pediatric and young adult autoimmune liver disease, splenic T1 was associated with radiologic and clinical fibrosis markers, including radiologic portal hypertension.
Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis
Parisinos, C. A., et al. (2020)
Journal of Hepatology
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GWAS study of cT1 (LiverMultiScan) in 14,440 UK Biobank participants identified SLC39A as a genetic variant associated with fibro-inflammatory liver disease. Findings highlight SLC39A8 as a potential drug target and reinforce cT1 as a genetics-informed biomarker.
NGM282 improves liver fibrosis and histology in 12 weeks in patients with nonalcoholic steatohepatitis
Harrison, S. A., et al. (2020)
Journal of Hepatology
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Results from a Phase 2 NASH trial showing that LiverMultiScan (cT1) can detect drug efficacy in as little as 6 weeks to serve as an early go/no-go signal. cT1 differentiated responders, tracked changes, and correlated with histology and serum biomarkers, enabling sensitive, non-invasive longitudinal monitoring.
Quantitative MRCP Imaging: Accuracy, repeatability, reproducibility, and cohort-derived normative ranges
Goldfinger, M., et al. (2020)
Journal of Magnetic Resonance Imaging
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Quantitative MRCP (MRCP+) is an accurate, repeatable and reproducible method. Compared with qualitative MRCP, MRCP+ reduces subjectivity, quantifies duct diameters along the biliary tree, and detects candidate strictures and dilatations with high sensitivity and specificity. Quantitative MRCP improves upon the current “gold standard” of noninvasive imaging of the biliary tree.
Nutrition and nonalcoholic fatty liver disease – Current perspectives
Chakravarthy, M. V., et al. (2020)
Gastroenterology Clinics
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Nutrition-focused review of NAFLD/NASH: how macro- and micronutrients shape disease biology and overlap with drug targets. Lifestyle modification remains first-line therapy. The review also offers a practical dietary framework to integrate with medical management and address cardiometabolic risk.
Repeatability and reproducibility of multiparametric magnetic resonance imaging of the liver
Bachtiar, V., et al. (2019)
PLoS One
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Technical validation of LiverMultiScan demonstrating good reproducibility and repeatability for quantifying liver tissue characteristics across different MR vendors and field strengths. Standardized biomarkers with low variability, like LiverMultiScan, are crucial for reliable readings in longitudinal monitoring in multicentre clinical trials.
Sodium-glucose cotransporter 2 inhibition does not reduce hepatic steatosis in overweight, insulin-resistant patients without type 2 diabetes
Marjot, T., et al. (2019)
JGH Open
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LiverMultiScan’s cT1 was used alongside other technologies to identify new indications for existing type 2 diabetes drugs. cT1 confirmed an absence of treatment effect of dapagliflozin in this small NAFLD cohort.
Non-invasive assessment of portal hypertension by multi-parametric magnetic resonance imaging of the spleen: A proof of concept study
Levick, C., et al. (2019)
PLOS ONE
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Proof-of-concept evaluation of multi-parametric MRI (LiverMultiScan) for non-invasive assessment of portal hypertension. Spleen cT1 emerged as a promising marker of portal pressure, outperforming established non-invasive scores and indicating potential for safer, more accurate monitoring.
Differentiating pediatric autoimmune liver diseases by quantitative magnetic resonance cholangiopancreatography
Gilligan, L. A., et al. (2019)
Abdominal Radiology
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Quantitative MRCP+ outperformed serum biochemistry in differentiating paediatric PSC/ASC from AIH: all but one MRCP+ parameter significantly differed between cohorts and predicted diagnosis, whereas no laboratory values were significantly different between cohorts. Findings highlight MRCP+ as a useful non-invasive tool providing multiple imaging biomarkers of autoimmune liver disease.
Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration
Wilman, H. R., et al. (2019)
Journal of Hepatology
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Three genetic variants that are linked to an increased risk of developing higher liver iron content were identified. Mendelian randomisation analysis provided evidence that higher central obesity plays a causal role in increased liver iron content.
Magnitude-intrinsic water–fat ambiguity can be resolved with multipeak fat modeling and a multipoint search method
Bagur, A., et al. (2019)
Magnetic Resonance in Medicine
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Technical validation of LiverMultiScan technique (MAGO) for measurement of liver fat: MAGO showed excellent accuracy and reproducibility across MR vendors at different field strengths. Technically challenging cases were processable with MAGO, demonstrating robustness of the technique.
Noninvasive assessment of liver disease in patients with nonalcoholic fatty liver disease
Castera, L. et al. (2019)
Reviews in Basic and Clinical Gasteroenterology and Hepatology
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Review of non-invasive methods for assessing liver disease in NAFLD and how they could be used in clinical practice. Highlights the key issues of differentiating NASH from simple steatosis and identifying advanced fibrosis.
Diagnostic performance of quantitative magnetic resonance imaging biomarkers for predicting portal hypertension in children and young adults with autoimmune liver disease
Dillman, J., et al. (2019)
Pediatric Radiology
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Evaluates the utility of quantitative MRI biomarkers including elastography and cT1 mapping for predicting portal hypertension in a paediatric population. Liver and spleen stiffness, along with liver cT1, predict radiologic portal hypertension with good accuracy.