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Measurement of liver iron by magnetic resonance imaging in the UK Biobank population
McKay, A., et al. (2018)
PloS One
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LiverMultiScan was used to quantify hepatic iron levels in 9,108 UK Biobank participants, demonstrating feasibility for large-scale, non-invasive population assessment of liver iron with this technique.
Mapping tissue water T(1) in the liver using the MOLLI T(1) method in the presence of fat, iron and B(0) inhomogeneity
Mozes, F. E., et al. (2018)
NMR in Biomedicine
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Describes a method for computing a “water T1” by correcting the MOLLI T1 for the confounding influence of iron, fat, and frequency offsets. This has the potential to improve the characterisation of fibro-inflammatory liver disease.
Validation of a standardized method for liver fat and T2* quantification
Hutton, C., et al. (2018)
PloS One
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Technical validation of the LiverMultiScan technique (LMS IDEAL) for liver fat quantification: high accuracy and excellent reproducibility across major MR vendors and field strengths and over a wide range of values. Perspectum is the only imaging provider with the IDEAL technique standardized across vendors, enabling consistent, scalable multi-site deployment.
Current status of imaging in nonalcoholic fatty liver disease
Li, Q., et al. (2018)
World Journal of Hepatology
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Review of imaging methods for NAFLD risk stratification and management, including multiparametric MRI (LiverMultiScan), MR Elastography and Ultrasound Elastography.
Reference range of liver corrected T1 values in a population at low risk for fatty liver disease: a UK Biobank sub-study with an appendix of interesting cases
Mojtahed, A., et al. (2018)
Abdominal Radiology
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This study establishes cT1 reference ranges in a large, low-risk UK Biobank cohort, which serves as a benchmark for normal liver, aids clinical interpretation and study design, reinforcing cT1 as a reliable quantitative biomarker for liver health and disease.
Study Protocol: HepaT1ca – An observational clinical cohort study to quantify liver health in surgical candidates for liver malignancies
Mole, D. J., et al. (2018)
BMC Cancer
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This ongoing trial will refine the technology and clinical application of LiverMultiScan in quantifying pre-existing liver health and predicting post-intervention outcomes following liver resection in cancer.
Utility and variability of three non-invasive liver fibrosis imaging modalities to evaluate efficacy of GR-MD-02 in subjects with NASH and bridging fibrosis during a phase-2 controlled study
Harrison, S., et al. (2018)
PloS One
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cT1 showed superior reproducibility (CoV 3.1%) compared to the other non-invasive liver tests used in this NASH clinical trial: magnetic resonance elastography (MRE, CoV 11%) and transient elastography (TE, 40%). This underscores utility of cT1 as a sensitive, reliable marker for monitoring longitudinal change in NASH patients.
Non-invasive assessment of liver disease in rats using multiparametric magnetic resonance imaging: A feasibility study
Hoy, A. M., et al. (2018)
Biology Open
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LiverMultiScan accurately quantified levels of hepatic fibroinflammation, fat, and iron in preclinical models.
Multiparametric magnetic resonance imaging for quantitation of liver disease: a two-centre cross-sectional observational study
McDonald, N., et al. (2018)
Scientific Reports
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LiverMultiScan achieved a 98.1% technical success rate—including in obesity—outperforming transient elastography (85%). It showed excellent repeatability and reproducibility and strong diagnostic accuracy for hepatic fibroinflammation, fat, and iron.
Multiparametric magnetic resonance imaging for early detection of diffuse liver disease
Breen, D. (2018)
Biomarkers in Medicine
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From a radiologist’s perspective, LiverMultiScan delivers early, non-invasive detection of diffuse liver disease with reproducible, decision-ready biomarkers. It reduces biopsies, outperforms other non-invasive tests, and drives cost-effective patient stratification and monitoring, helping providers act sooner and health systems save more.
Utility and cost evaluation of multiparametric magnetic resonance imaging for the assessment of non-alcoholic fatty liver disease
Eddowes, P., et al. (2017)
Alimentary Pharmacology & Therapeutics
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LiverMultiScan accurately identified patients with steatosis, stratified those with NASH, and reliably excluded clinically significant liver disease, with superior negative predictive value (83.3%) vs. transient elastography (42.9%) and ELF (57.1%). For NAFLD risk stratification, LiverMultiScan was cost-effective and, when combined with transient elastography, delivered the lowest cost per correct diagnosis.
Interobserver variability in histologic evaluation of liver fibrosis using categorical and quantitative scores
Pavlides, M., et al. (2017)
American Journal of Clinical Pathology
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Assessment of liver fibrosis by digital imaging analysis of Collagen Proportionate Area (CPA) followed by visual assessment of CPA is more robust than visual analysis alone with improved agreement between pathologists.
Characterisation of liver fat in the UK Biobank cohort
Wilman, H. R., et al. (2017)
PloS One
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LiverMultiScan was used to measure hepatic fat in ~5,000 participants in the UK Biobank with a success rate of 96.8% and acquisition time of 3 minutes, enabling cost-effective population screening at scale.
Multiparametric magnetic resonance imaging for the assessment of non-alcoholic fatty liver disease severity
Pavlides, M., et al. (2016)
Liver International
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LiverMultiScan had a higher success rate in NAFLD patients (95%) compared to transient elastography (59%), and showed high accuracy for the diagnosis of NASH and ballooning. This demonstrates potential application in patient management and supports use as a surrogate endpoint in clinical trials.