Filters
Repeatability, Reproducibility, and Observer Variability of Cortical T1 Mapping for Renal Tissue Characterization
Nowak, M., et al. (2024)
Journal of Magnetic Resonance Imaging
Read Summary ▾
Kidney cortical T1 mapping is a highly repeatable and reproducible method across MRI manufacturers, field strengths, and operator conditions. The standardized methodological consistency paves the way for its adoption in multi-centre clinical trials.
Gamma-glutamyl transferase: a potential biomarker for pancreas steatosis in patients with concurrent obesity, insulin resistance and metabolic dysfunction-associated steatotic liver disease
Chiyanika, C., et al. (2024)
Clinical obesity
Read Summary ▾
This study demonstrates clinical benefits of combining imaging markers with blood markers, such as GGT, in patients without a history of pancreatitis who have obesity and MASLD. Pairing LiverMultiScan with standard blood markers enables early identification and risk stratification of fatty pancreas in individuals with MASLD.
Fighting amyotrophic lateral sclerosis by protecting the liver? A prospective cohort study
Zhu, L., et al. (2024)
Annals of Neurology
Read Summary ▾
Multiparametric MRI, including cT1, was used to non-invasively monitor treatment response to lanifibranor in NASH. cT1 was significantly reduced after 24 weeks of treatment compared to placebo, indicating reduced hepatic fibroinflammation. Moreover, cT1 change was associated with histologic improvements in SAF activity score, supporting cT1 as a sensitive, non-invasive imaging biomarker for assessing therapeutic response in NASH
Reference Range of Quantitative MRI Metrics Corrected T1 and Liver Fat Content in Children and Young Adults: Pooled Participant Analysis
Shumbayawonda, E., et al. (2024)
Children
Read Summary ▾
Multi-centre pooled analysis established reference ranges for cT1 and PDFF in healthy children and young adults. Values were normally distributed (median cT1 748 ms; PDFF 1.7%) and within the reported normal limits (<800 ms; <5%). Age comparisons showed clinically negligible cT1 and PDFF differences differences between paediatric and adult groups.
A flavonoid-rich diet is associated with lower risk and improved imaging biomarkers of nonalcoholic fatty liver disease: A prospective cohort study
Bell, W., et al. (2024)
The American Journal of Clinical Nutrition
Read Summary ▾
Higher dietary flavonoid intake was linked to lower risk of NAFLD. Participants with the highest flavonoid-rich diet scores had significantly lower cT1 values than those with the lowest scores. Tea, red wine, and sweet peppers were particularly associated with reduced cT1, suggesting flavonoid-rich diets may help lower risk for NAFLD.
Decreases in cT1 and liver fat content reflect histological improvement induced by therapies in MASH: a multicentre pooled coho rt analysis.
Alkhouri, N., et al. (2024)
Journal of Hepatology
Read Summary ▾
Across three multicentre trials, changes in cT1 and PDFF predicted histologic response to MASH therapy. A reduction in cT1 of -80 ms was associated with a 5-fold increase in the odds of achieving resolution of steatohepatitis, a 30% PDFF reduction had roughly fourfold higher odds, while the optimal threshold of -58% had sevenfold higher odds.
Quantitative MRI for monitoring metabolic dysfunction associated steatotic liver disease: A test-retest repeatability study
Beyer, C., et al. (2024)
JMRI
Read Summary ▾
This study demonstrates the accuracy and reproducibility of LiverMultiScan metrics (cT1 and PDFF) in patients with MASH and MASLD. The results quantify the minimal detectable (absolute) changes in cT1 (32 ms) and liver fat fraction (0.6%) that discern measurement error from real change when monitoring patients with MASLD on a single scanner.
Feasibility of using contrast-free quantitative magnetic resonance imaging for liver sparing stereotactic ablative body radiotherapy
Brewster, F., et al. (2024)
Clinical and Translational Radiation Oncology
Read Summary ▾
In liver metastases, functional liver volumes automatically segmented using cT1 maps were used to create liver-sparing plans, which significantly reduced the functional liver mean dose versus standard planning. This first demonstration of cT1-guided stereotactic ablative radiotherapy suggests a route to spare healthy liver, though validation in liver cancer cohorts is required.
The Glutamate-Serine-Glycine Index as a Biomarker to Monitor the Effects of Bariatric Surgery on Non-alcoholic Fatty Liver Disease
Tan., et al. (2024)
Journal of the ASEAN Federation of Endocrine Societies
Read Summary ▾
In a longitudinal bariatric surgery case series, liver fat (PDFF), cT1, and the glutamate–serine–glycine (GSG) index all showed reductions postoperatively. These findings support integrating blood and imaging biomarkers to monitor improvement and guide interventions.
T1 Mapping of the Abdomen, From the AJR “How We Do It” Special Series
Serai, S. D., et al. (2024)
American Journal of Roentgenology
Read Summary ▾
Technical overview of quantitative MRI advancements including abdominal T1 mapping of liver, pancreas, and kidneys. T1 mapping produces color-coded maps that highlight changes related to inflammation and fibrosis, aiding in diagnoses like liver fibro-inflammation. Standardized methods are emphasized to improve diagnostic accuracy and enable reliable longitudinal assessment.
Assessing the performance of AI‐assisted technicians in liver segmentation, Couinaud division, and lesion detection: a pilot study
Nunez, L., et al. (2024)
Hepatobiliary
Read Summary ▾
An AI-assisted workflow allowed non-radiologists to perform liver delineation, Couinaud segmentation, and lesion detection on MRI with accuracy comparable to radiologists, reducing workload. Agreement on whole-liver volume and segment measurements was high, and all lesions identified by radiologists were found; non-radiologists also flagged additional lesions confirmed by external adjudicator radiologists.
Risk of Type 2 Diabetes, Metabolic Dysfunction Associated Steatotic Liver Disease and Cardiovascular Disease in People Living with Polycystic Ovary Syndrome According to Disease Phenotype: An Analysis of Prospective Cohort and Multi-Organ Imaging Data from the UK Biobank.
Henney, A. E, et al. (2024)
The Lancet
Read Summary ▾
In UK Biobank, women with PCOS had greater prevalence and incidence of type 2 diabetes, steatotic liver disease, and all-cause cardiovascular disease. Liver MRI showed more severe steatosis and higher fibroinflammation by cT1. These comorbidities are increased in older PCOS patients with a disease phenotype-specific pattern.
The effectiveness of magnetic resonance imaging (MRI) iron corrected T1 in monitoring metabolic dysfunction-associated steatohepatitis in obesity following bariatric surgery and lifestyle modification: a prospective cohort study
Chiyanika, C., et al. (2024)
Quantitative Imaging in Medicine and Surgery
Read Summary ▾
Among adults with obesity and MASLD, MRI biomarkers, including cT1, assessed liver health and identified MASH with high accuracy. Bariatric surgery achieved greater reductions in cT1 and PDFF than lifestyle modification, indicating superior improvement in liver health and supporting cT1 for monitoring treatment response.
Tirzepatide for Metabolic Dysfunction – Associated Steatohepatitis with Liver Fibrosis
Loomba, R., et al. (2024)
NEJM
Read Summary ▾
Over 52 weeks, weekly tirzepatide significantly increased MASH resolution without fibrosis worsening in biopsy-confirmed MASH with F2–F3 fibrosis. It also showed improvement of at least one fibrosis stage without worsening MASH. cT1 was significantly reduced in the treatment group compared to placebo, showing a dose-dependent reduction.