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EASL–EASD–EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)
Tacke, F., et al. (2024)
Journal of Hepatology
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Guidelines note an indirect MRI method for MASH and fibrosis diagnostics, LiverMultiScan, that can be performed on standard scanners without an elastography unit. By generating iron-corrected T1 (cT1) maps from T1 and T2* data, it estimates extracellular volume, reflecting inflammatory activity and fibrosis, aiding MASH and fibrosis assessment.
Multi-organ abnormalities assessed by a single MRI scan in individuals with blood cancer
Reed, S., et al. (2024)
European J Internal Medicine
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CoverScan efficiently detects multi-organ abnormalities in patients with blood cancer, enabling more personalised treatment and potentially better outcomes. Compared with healthy controls, multi-organ impairment was more frequent, predominantly affecting the spleen and kidneys.
Quantitative imaging reveals steatosis and fibro-inflammation in multiple organs in people with type 2 diabetes: a real-world study
Diamond, C., et al. (2024)
Diabetes
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The first comprehensive analysis of multi-organ steatosis and fibro-inflammation in people living with obesity and type 2 diabetes receiving routine hospital care. Those on weight loss treatments saw improvements in organ health that did not occur in patients on metformin, highlighting the measurable and visible impact of weight-loss therapies in real-world patients.
Quantitative MRCP and metrics of bile duct disease over time in patients with primary sclerosing cholangitis: A prospective study
Trivedi, P. J, et al. (2024)
AP&T
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MRCP+ metrics differentiated between AIH, PBC and PSC, highlighting its potential as an adjunctive diagnostic tool. In PSC, baseline strictures and bile-duct metrics correlated with Modified Amsterdam Score, transient elastography, and ALP. Over one year, strictures increased in more than half of patients, while biochemistry, elastography, or Amsterdam Score showed no change.
Quantitative digital pathology enables automated and quantitative assessment of inflammatory activity in patients with autoimmune hepatitis
Socha, P., et al. (2024)
Journal of Pathology Informatics
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Quantitative digital pathology objectively measures inflammatory activity in autoimmune hepatitis, showing strong concordance with consensus histological assessment. By quantifying inflamed tissue area and inflammatory foci density on whole-slide images, the approach enables automated assessment, better stratification, and identification of patients with more advanced inflammatory disease.
Novel multimetric MRI detects improved future liver remnant quality post-dual vein embolization
Sundaravadanan, S., et al. (2024)
HPB
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Hepatica showed a significant improvement in future liver remnant (FLR) health, measured by cT1 and PDFF, in 10 consecutive patients with liver metastasis and insufficient FLR after undergoing dual vein embolization in the Precision1 clinical trial. “This is a significant advance in our understanding of how to prevent liver failure in patients undergoing major liver surgery.”
Pilot feasibility study to determine the utility of direct access and quantitative magnetic resonance cholangiopancreatography (MRCP) in the assessment of suspected acute biliary or ductal gallstone presentations
Novak et al. (2024)
BMC Gastroenterology
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In suspected acute biliary or ductal gallstone presentations, first-line MRCP outperformed ultrasound-led standard care—delivering quicker, more cost-effective diagnosis and obstruction detection. MRCP+ also quantified gallbladder volume and cystic duct width, adding value for triage and management and supporting direct-access MRCP pathways.
Genetic risk amplifies lifestyle effects on hepatic steatosis and its progression: Insights from a population-based cohort
Zhang, X., et al. (2024)
Digestive and Liver Disease
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Genetic risk and lifestyle factors influence steatotic liver disease and cardiovascular events. Lifestyle effects were stronger in individuals with higher genetic risk, especially if overweight. Genetic factors, physical activity, and sleep duration interacted to influence cT1 and cardiovascular events. Targeted lifestyle interventions could be particularly effective in genetically susceptible populations.
Intrapancreatic fat deposition is unrelated to liver steatosis in metabolic dysfunction-associated steatotic liver disease
Mak, A. L., et al. (2024)
JHEP Reports
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The study included pancreatic T1/PDFF and hepatic cT1/PDFF measures to assess pancreas–liver relationships in MASLD. Intrapancreatic fat deposition was not associated with hepatic steatosis. Pancreatic T1 was increased across disease stages, consistent with pancreatic inflammation in individuals with impaired glucose homeostasis.
Prognostic models and autoimmune liver diseases. Best Practice & Research
D’Amato, D., et al. (2023)
Clinical Gastroenterology
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Review of prognostic tools for the clinical management of patients with AILD. In AIH, LiverMultiScan cT1, an objective, accurate measure of fibro-inflammation, may be determinant in clinical decision-making and could substitute liver biopsy in follow-up. It also outlines the prognostic value of MRCP+ for PSC management.
Reply to: Reassessing the causal relationship between liver diseases and cardiovascular outcomes and to: From Liver to Heart: Enhancing the Understanding of Cardiovascular Outcomes in the UK Biobank
Thomaides-Brears, H. B., et al. (2023)
Journal of Hepatology
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This opinion piece states that MASLD is an obesity-related condition that requires both imaging- and genetic-risk tools for a comprehensive picture of multi-organ associations. Without imaging data, genetic tools such as the Mendelian randomisation method alone may not provide clinically relevant information on liver health and cardiovascular risk in patients with MASLD.
Liver investigation: Testing marker utility in steatohepatitis (LITMUS): Assessment & validation of imaging modality performance across the NAFLD spectrum in a prospectively recruited cohort study (the LITMUS imaging study): Study protocol
Pavlides, M., et al. (2023)
Contemporary Clinical Trials
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The protocol for the LITMUS Imaging Study, a prospective multi-centre cohort study on adults with NAFLD, evaluating non-invasive imaging tools (LiverMultiScan, MR elastography, and ultrasound elastography) against liver histology as the reference standard. The goal is to identify the imaging tools that accurately stage the severity of liver fibrosis in people with NAFLD.
A snapshot of digital transformation in hepatology and rare liver disease related health care: A UK perspective
Ala, A., et al. (2023)
Mayo Clinic Proceedings: Digital Health
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An editorial on UK digital hepatology highlights the diagnostic and prognostic value of LiverMultiScan and MRCP+ in AILDs. LiverMultiScan’s cT1 has a prognostic value as it correlates with the risk of loss of biochemical remission in AIH. MRCP+ correlates with validated risk scoring systems and may improve diagnosis and prognostic models in primary PSC.
Cardiovascular imaging in the integrated assessment of metabolic health
Thomaides-Brears, H. B., et al. (2023)
Frontiers in Cardiovascular Medicine
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This editorial provides insights into the clinical utility of multi-modal imaging to study metabolic diseases with organ-specific and extra-organ manifestations requiring integrated care: “the multisystem nature of metabolic disease puts multiorgan imaging front and centre for integration of care to avoid putting patients at risk of the complications associated with biopsy”.