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Quantitative magnetic resonance cholangiopancreatography is associated with severity and outcomes in Primary Sclerosing Cholangitis
Cazzagon, N., et al. (2022)
JHEP Reports
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Quantitative MRCP metrics in large-duct PSC correlated with established prognostic factors, ANALI (morphological scores based on MRCP images), liver stiffness (VCTE), and biochemical scores. Median duct diameter was associated with outcomes, underscoring quantitative MRCP’s prognostic value in patients with PSC.
Nonalcoholic fatty liver disease: Review of management for primary care providers
Basu, R., et al. (2022)
Mayo Clinic Proceedings
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This article reviews the evaluation, diagnosis, and management of adults with NAFLD/NASH in the primary care setting and endocrinology clinics. LiverMultiScan was cited as a potential tool for liver imaging and assessment to ensure prompt diagnosis of NAFLD/NASH in routine practice.
AGA clinical practice update: Diagnosis and management of nonalcoholic fatty liver disease in lean individuals: Expert review
Long, M. T., et al. (2022)
Gastroenterology
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This American Gastroenterological Association (AGA) clinical practice update provides best practice advice on evidence-based approaches diagnosis, staging, and management of NAFLD in lean individuals. It recommends combining noninvasive biomarkers, such as cT1, with fibrosis tests (VCTE, MRE, and EFL) to identify and risk-stratify lean patients with NASH for most appropriate treatment.
MRI in liver cirrhosis
Alzoubi, O., et al. (2022)
Portal Hypertension & Cirrhosis
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Review advocates streamlined, noninvasive pathways for cirrhosis assessment, replacing fragmented diagnostics and biopsies. LiverMultiScan cT1 is highlighted as a fast, fully noninvasive biomarker that can simplify clinical pathways, support diagnosis and screening of liver diseases, and reduce clinic burden.
American Association of Clinical Endocrinology Clinical Practice Guideline for the diagnosis and management of nonalcoholic fatty liver disease in primary care and endocrinology clinical settings: Co-sponsored by AASLD
Cusi, K., et al. (2022)
Endocrine Practice
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AACE guideline provides evidence-based recommendations for NAFLD/NASH diagnosis and management in primary care and endocrinology. Its cirrhosis-prevention algorithm advises referring patients at indeterminate or high fibrosis risk for specialist evaluation using advanced noninvasive biomarkers, including cT1 (LiverMultiScan), to refine staging and guide care.
Greater ectopic fat deposition, liver fibroinflammation and lower skeletal muscle mass in people with type 2 diabetes
Waddell, T., et al. (2022)
Obesity
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UK Biobank analysis shows that people with type 2 diabetes have higher liver fat (PDFF) and fibro-inflammation (cT1) and lower skeletal muscle index than non-diabetic controls. In addition, LiverMultiScan detected greater liver damage in participants with T2D despite normal liver biochemistry (AST/ALT).
Quantitative MR in paediatric patients with Wilson Disease: A case series review
Janowski, K., et al. (2022)
Children
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In pediatric Wilson disease, LiverMultiScan’s cT1 and PDFF correlated with histological scores of fibrosis, inflammation, and steatosis, whereas ultrasound did not. MRCP+ identified dilatations in the biliary tree, not detected during the standard of care examination.
A rare genetic variant in the manganese transporter SLC30A10 and elevated liver enzymes in the general population
Seidelin, A. S., et al. (2022)
Hepatology International
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A rare genetic variant (SLC30A10 p.Thr95Ile) is associated with elevated ALT and higher cT1 measured by LiverMultiScan, markers of liver fibro-inflammation, indicating the variant may increase liver-disease risk in the general population.
The additive value of cardiovascular magnetic resonance in convalescent COVID-19 patients
Borlotti, A., et al. (2022)
Frontiers in Cardiovascular Medicine
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This review highlights CMR’s value in convalescent COVID-19, revealing frequent myocardial abnormalities months after infection. CMR also enabled the identification of multi-organ damage, indicating the importance of further investigation into the relationship between cardiac injury, ongoing symptoms, pre-existing risk factors, and damage to other organs.
Genetic variants of glycogen metabolism genes were associated with liver PDFF without increasing NAFLD risk
Yang, L., et al. (2022)
Frontiers in Genetics
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In a UK Biobank secondary analysis using LiverMultiScan, variants in glycogen-metabolism genes associated with MRI-PDFF were not linked to NAFLD risk, suggesting hepatic glycogen can bias PDFF and should be considered when interpreting MRI-based liver fat measurements.
Precision medicine for liver tumours with quantitative magnetic resonance imaging and whole genome sequencing (Precision1 trial): Study protocol for observational cohort study
Welsh, F., et al. (2022)
BMJ Open
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Study protocol for Precision1 trial: an observational radiogenomics cohort in liver tumours. Primary endpoint: proportion of patients whose management would change based on whole-genome sequencing. Secondary aims assess decision impact of LiverMultiScan- and Hepatica, and correlate quantitative MRI with genomic and histologic features to guide precision care.
Magnetic resonance imaging metrics and the predictability of adverse outcomes in on-treatment Asian chronic hepatitis B
Hui, R. W., et al. (2022)
Journal of Gastroenterology and Hepatology
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In treated chronic hepatitis B with advanced fibrosis, liver iron quantified by LiverMultiScan predicted hepatocellular carcinoma (HCC) occurrence over 2 years. The same scan also assessed the pancreas, supporting a single, noninvasive workflow for longitudinal monitoring and prognostication in chronic hepatitis B.
A quantitative magnetic resonance cholangiopancreatography metric of intrahepatic biliary dilatation severity detects high-risk primary sclerosing cholangitis
Selvaraj, E. A., et al. (2022)
Hepatology Communications
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In large-duct PSC, MRCP+ quantification of biliary dilatation identified high-risk patients and showed superior interobserver agreement when compared to qualitative MRCP, supporting MRCP+ for objective risk stratification and consistent reporting.
4D flow cardiovascular magnetic resonance derived energetics in the Fontan circulation correlate with exercise capacity and CMR-derived liver fibrosis/congestion
Rijnberg, F. M., et al. (2022)
Journal of Cardiovascular Magnetic Resonance
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In Fontan circulation, higher liver cT1 (fibrosis/congestion) correlated with impaired exercise capacity and adverse 4D blood flow measured with CMR. Findings link hepatic injury to hemodynamic inefficiency, supporting combined 4D flow CMR and LiverMultiScan for noninvasive risk assessment.