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A 3D quantitative MRC modeling images detected case of intrahepatic biliary stricture diseases
Nanashima, A., et al. (2021)
Case Reports in Gastroenterology
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Case report using MRCP+ to convert MRCP into 3D biliary maps with quantitative metrics. Intrahepatic biliary stricture disease showed distinct ductal abnormalities versus controls. MRCP+ visualized and quantified strictures and dilatations across the entire tree at a glance, supporting earlier detection of subtle intrahepatic biliary disease.
Evaluation of quantitative MRCP (MRCP+) for risk stratification of primary sclerosing cholangitis: comparison with morphological MRCP, MR elastography, and biochemical risk scores
Ismail, M. F., et al. (2021)
European Radiology
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In PSC, MRCP+ quantitative duct metrics correlated with biochemical risk scores and MR elastography, with performance comparable to ANALI morphological scores. Combining MRCP+ with ANALI or with MRE improved association with the Mayo Risk Score, supporting integrated imaging and morphology for noninvasive risk assessment.
Incidence of complications from percutaneous biopsy in chronic liver disease: a systematic review and meta-analysis
Thomaides-Brears, H., et al. (2021)
Digestive Diseases and Sciences
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Review of incidence of all complications and technical failure associated with percutaneous liver biopsy shows notable risk: major complications ~2% (mostly bleeding), minor ~10% (mostly pain), and ~1% technical failure. These findings support consideration of standardized, noninvasive alternatives for diagnosis and monitoring.
Multiparametric MRI imaging, autoimmune hepatitis, and prediction of disease activity
Arndtz, K., et al. (2021)
Hepatology Communications
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In AIH, failure to maintain remission was associated with increased cT1, not FibroScan liver stiffness or ELF. Baseline cT1 also predicted subsequent biochemical relapse, whereas liver stiffness or ELF did not, supporting LiverMultiScan as a sensitive tool for risk stratification and earlier intervention.
The effect of multiparametric magnetic resonance imaging in standard of care for non-alcoholic fatty liver disease: Protocol for a randomised control trial
Tonev, D., et al. (2021)
JMIR Research Protocols
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Protocol for RADIcAL1 study: a multi-centre, two-arm RCT across four European countries testing whether standardized mpMRI (LiverMultiScan) as a diagnostic test for suspected NAFLD in tertiary hepatology clinics is cost-effective versus current pathways (consultations and/or liver biopsy) in over 1072 adults.
Comparison between magnetic resonance and ultrasound-derived indicators of hepatic steatosis in a pooled NAFLD cohort
Beyer, C., et al. (2021)
Plos One
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Biopsy-referenced comparison in NAFLD: LiverMultiScan PDFF performed well across all steatosis grades, while CAP (ultrasound) was adequate at lower fat levels but inferior to liver PDFF for moderate–severe steatosis. This supports MRI-PDFF as the preferred noninvasive metric when precise quantification is needed.
Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: a prospective, community-based study
Dennis, A., et al. (2021)
BMJ Open
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Prospective community study of low-risk individuals with persistent post-COVID symptoms found widespread multi-organ involvement months after infection, affecting the heart, lungs, kidneys, pancreas and liver, with cardiac impairment more frequent in severe cases. These findings demonstrate feasibility and value of community-based, multiparametric assessment to guide management before and after infection.
Hepatic steatosis rather than underlying obesity increases risk of infection and hospitalization for COVID-19
Roca-Fernandez, A., et al. (2021)
Frontiers in Medicine Gastroenterology
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In a large-scale UK Biobank study, hepatic steatosis, not obesity alone, predicted COVID-19 severity: obese individuals with elevated liver fat had ~5-fold higher hospitalization risk. LiverMultiScan can quantify liver fat to stratify risk and support public health policy, clinical triage, and targeted lifestyle interventions.
Prospective evaluation of the prevalence of non-alcoholic fatty liver disease and steatohepatitis in a large middle-aged US cohort
Harrison, S., et al. (2021)
Journal of Hepatology
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In asymptomatic, middle-aged U.S. adults, LiverMultiScan PDFF estimated NAFLD prevalence at 38% and biopsy-confirmed NASH prevalence was 14%. NASH associated with race, obesity, and diabetes. These findings underscore LiverMultiScan’s suitability for scalable population assessment to identify at-risk individuals and enrich NASH cohorts.
Effect of Mastiha supplementation on NAFLD: The MAST4HEALTH Randomised, Controlled Trial
Amerikanou, C., et al. (2021)
Molecular Nutrition & Food Research
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LiverMultiScan’s cT1 was the primary endpoint in a multicenter, randomized, double-blind, placebo-controlled trial on the effect of Mastiha on liver inflammation and fibrosis. Over six months, cT1 decreased in participants with severe obesity, with no significant change on placebo.
Quantitative multiparametric MRI can aid NASH diagnosis in a Japanese cohort
Imajo, K., et al. (2021)
World Journal of Gastroenterology
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Comparative study in patients with historical diagnosis of NAFLD or suspected of NAFLD showed that cT1 and PDFF (LiverMultiScan) outperformed FibroScan, MRE, and SWE for identifying NASH, providing strong evidence for clinical adoption.
Correlations between MRI biomarkers PDFF and cT1 with histopathological features of non-alcoholic steatohepatitis
Dennis, A., et al. (2021)
Frontiers in Endocrinology
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The correlations between cT1 and PDFF with the histopathological hallmarks of NASH demonstrate the potential utility of both cT1 and PDFF as non-invasive biomarkers to detect a pharmacodynamic change in NASH, with cT1 showing superiority for detecting changes in inflammation and fibrosis, rather than liver fat alone.
Quantitative multiparametric MRI allows safe surgical planning in patients undergoing liver resection for colorectal liver metastases: report of two patients
Sethi, P., et al. (2021)
BJR Case Reports
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Case report. Two colorectal liver metastasis resections with contrasting outcomes: retrospective pre-op Hepatica revealed high cT1 and PDFF in the patient who developed complications and prolonged stay, versus normal cT1 and PDFF in the short-stay case with no complications, indicating quantitative mpMRI can flag at-risk patients and guide safer surgical planning.
Magnetic resonance imaging predicts individual future liver performance after liver resection for cancer
Mole, D. J., et al. (2020)
PLOS ONE
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This study highlights the utility of Hepatica for identifying patients at increased risk of poor post-operative liver performance and longer hospital stay. Pre-operative cT1 predicts length of post-operative hospital stay and has potential to inform the individualised risk assessment and surgical decision-making for liver cancer surgery.