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Liver cT1 decreases following direct-acting antiviral therapy in patients with chronic hepatitis C virus
Jayaswal, A., et al. (2020)
Abdominal Radiology
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LiverMultiScan’s cT1 decreased in patients with chronic hepatitis C virus (HCV) undergoing direct-acting antiviral therapy. The fast reduction in cT1 is consistent with reduced inflammation rather than fibrosis regression, supporting LiverMultiScan as a sensitive biomarker for treatment monitoring.
Serum Matrix Metalloproteinase 7 Is a Diagnostic Biomarker of Biliary Injury and Fibrosis in Pediatric Autoimmune Liver Disease
Lam, S., et al. (2020)
Hepatology Communications
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Serum MMP7 was evaluated as a biomarker for sclerosing cholangitis in paediatric patients with autoimmune liver disease (AILD). Higher sMMP7 levels associated with histologic bile duct injury and hepatic fibrosis, and on MRCP+ correlated with the number of biliary dilatations and strictures, supporting sMMP7 as a noninvasive indicator of ductal disease severity.
A composite biomarker using multiparametric magnetic resonance imaging and blood analytes accurately identifies patients with non-alcoholic steatohepatitis and significant fibrosis
Dennis, A., et al. (2020)
Scientific Reports
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In biopsy-confirmed NAFLD, LiverMultiScan’s cT1, blood-based AST, GGT, and fasting glucose predicted significant fibrosis. The combined cTAG score (cT1+AST+glucose) outperformed individual markers, highlighting its utility for screening patients prior to biopsy to identify those suitable for NASH clinical trial enrolment.
Multiparametric MRI as a non-invasive monitoring tool for children with autoimmune hepatitis
Janowski, K., et al. (2020)
Journal of Pediatric Gastroenterology and Nutrition
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In paediatric autoimmune hepatitis (AIH), LiverMultiScan’s cT1 correlated with biochemical markers of disease severity and detected active disease even when routine labs were normal. These findings support cT1 as a sensitive, non-invasive tool to aid monitoring in AIH and guide timely management.
rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis
Teo, K., et al. (2020)
Journal of Hepatology
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Meta-analysis of more than 42 studies, including UK Biobank and cohorts with LiverMultiScan fat quantification confirms that a common genetic variant is a risk factor for presence and severity of NAFLD in individuals of European descent.
Multiparametric MRI in patients with nonalcoholic fatty liver disease
Schaapman, J. J., et al. (2020)
Journal of Magnetic Resonance Imaging
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This review contains the first European guidance on multiparametric MRI, including cT1, for suspected NAFLD: outlines how to assess fibrosis and inflammation risk and suggests how clinical management and treatment monitoring can be improved.
Ethnic Differences in body fat deposition and liver fat content in two UK-based cohorts
Alenaini, W., et al. (2020)
Obesity
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This study across two independent UK cohorts found limited ethnic differences in body-fat depot distribution linked to metabolic disease, suggesting that alternative mechanisms should be investigated. In the UK Biobank cohort, LiverMultiScan measured PDFF using a standardized workflow, scalable for large populations and enabling consistent, cross-site comparisons.
Multiparametric MR mapping in clinical decision-making for diffuse liver disease
Thomaides-Brears, H. B., et al. (2020)
Abdominal Radiology
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This review of techniques for clinical decision-making in diffuse liver disease highlights the advantages of cT1 (LiverMultiScan), showing superior NASH diagnostic performance compared with MRE, which requires additional hardware and is confounded by even mild iron overload and inflammation, and compared with DWI, which currently lacks standardization.
Prognostic value of multiparametric magnetic resonance imaging, transient elastography and blood-based fibrosis markers in patients with chronic liver disease
Jayaswal, A., et al. (2020)
Liver International
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LiverMultiScan’s noninvasive MRI biomarker cT1 predicts clinical outcomes in liver disease patients, outperforming FibroScan’s transient elastography and FIB-4, with performance comparable to invasive liver biopsy. After accounting for high technical failure rates, FibroScan lost prognostic value—underscoring cT1 as a robust, noninvasive risk-stratification biomarker.
Pancreas Segmentation-Derived Biomarkers: Volume and Shape Metrics in the UK Biobank Imaging Study
Bagur, A. T., et al. (2020)
Medical Image Understanding and Analysis
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A new technique for group-wise registration and manifold learning of pancreas images could be used for automated quality control and to determine abnormal pancreas morphology, which might reflect different patterns of fat infiltration.
Segmentation of the Biliary Tree from MRCP Images via the Monogenic Signal
Ralli, G. P., et al. (2020)
Medical Image Understanding and Analysis
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Monogenic signal–based MRCP segmentation accurately detects bile ducts and quantifies duct diameters, outperforming the widely used Frangi vesselness filter—enhancing automated biliary tree delineation for quantitative MRCP.
Segmenting Hepatocellular Carcinoma in Multi-phase CT
Vogt, N., et al. (2020)
Medical Image Understanding and Analysis
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Radiology-inspired machine learning method combining complementary tumour characteristics from both arterial phase and portal venous phase CT images offers improved accuracy in automatically delineating liver lesions.
Mechanisms, screening modalities and treatment options for individuals with non-alcoholic fatty liver disease and type 2 diabetes
Hydes, T. J., et al. (2020)
Diabetic Medicine
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This review discusses bidirectional links between NAFLD and type 2 diabetes, recommends MAFLD nomenclature, and details screening with noninvasive tests/imaging for advanced fibrosis. Outlines lifestyle, glucose-lowering drugs, and metabolic surgery, noting extra-hepatic risks and medication considerations.
New boundaries of liver imaging: from morphology to function
Cruz, M., et al. (2020)
European Journal of Internal Medicine
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Modern liver imaging pairs structure with function: techniques such as multiparametric MRI deliver noninvasive surrogate biomarkers for focal and diffuse disease, supporting diagnosis, staging, and treatment monitoring.